金年会

当前位置:首页 > 脑立体定位仪 > 颅内微量给药导管
脑立体定位仪

颅内微量给药导管

时间:2021-06-28来源:本站作者:金年会仪器

详细介绍

脑室微量给药导管可固定在大鼠、小鼠的颅骨上,埋入脑部适当的深度,配合相应的PE给药导管、微量注射器或者微量注射泵使用,实现对大鼠、小鼠颅内的微量给药。


单套管颅内给药



整个套管由基座、注射内管、导管帽、锁紧螺帽组成:


单套管颅内给药植入脑室的示意图:


给药套管的详细构造及主要尺寸:


(长度单位:mm)


订购指南,需要确定以下几个尺寸:

D1:导管外径的尺寸;

L1:下探到脑室套管的长度(含颅骨和脑室)

L3:注射内管探出基座套管的长度;

L4:导管芯(也就是堵头)探出基座套管的长度;


单套管的型号,各个组成配件的货号和尺寸:



双套管颅内给药

适用于两种不同或相同的药物注射在两个不同的位置;


双套管的主要组成:


双套管颅内给药植入脑室的示意图:


双套管的详细构造及主要尺寸:



订购指南,需要确定以下几个尺寸:

D1:导管外径的尺寸;

L1:下探到脑室套管的长度(含颅骨和脑室)

P :两根导管的间距

L3:注射内管探出基座套管的长度;

L4:导管芯(也就是堵头)探出基座套管的长度;


双套管的型号,各个组成配件的货号和尺寸:

新生鼠适用型号:


小鼠、大鼠适用型:


大鼠适用型:



颅内微量注射实验,还需要用到以下相关的设备和工具:

脑立体定位仪、微量注射泵、微量进样器、PE给药导管、固定螺丝、颅骨钻等


脑立体定位仪,可根据需求有多种型号可供选择:大鼠适配型、小鼠适配型、单臂、双臂、数显型


 



定位仪适配微量注射泵

 


微量注射泵


 


PE给药导管


牙科水泥


 


固定螺丝


    


小动物颅骨钻

 


参考文献:

[1] Wahis J, Baudon A, Althammer F, et al. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents[J]. Nature neuroscience, 2021, 24(4): 529-541.

[2] Zhu Z, Ng D W H, Park H S, et al. 3D-printed multifunctional materials enabled by artificial-intelligence-assisted fabrication technologies[J]. Nature Reviews Materials, 2021, 6(1): 27-47.

[3] Wang L, Gillis-Smith S, Peng Y, et al. The coding of valence and identity in the mammalian taste system[J]. Nature, 2018, 558(7708): 127-131.

[4] Terburg D, Scheggia D, Del Rio R T, et al. The basolateral amygdala is essential for rapid escape: a human and rodent study[J]. Cell, 2018, 175(3): 723-735. e16.

[5] Peng Y, Gillis-Smith S, Jin H, et al. Sweet and bitter taste in the brain of awake behaving animals[J]. Nature, 2015, 527(7579): 512-515.

[6] Tye K M, Mirzabekov J J, Warden M R, et al. Dopamine neurons modulate neural encoding and expression of depression-related behaviour[J]. Nature, 2013, 493(7433): 537-541.

[7] Sotres-Bayon F, Sierra-Mercado D, Pardilla-Delgado E, et al. Gating of fear in prelimbic cortex by hippocampal and amygdala inputs[J]. Neuron, 2012, 76(4): 804-812.

[8] Pascoli V, Turiault M, Lüscher C. Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour[J]. Nature, 2012, 481(7379): 71-75.

[9] Lemos J C, Wanat M J, Smith J S, et al. Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive[J]. Nature, 2012, 490(7420): 402-406.

[10] Goshen I, Brodsky M, Prakash R, et al. Dynamics of retrieval strategies for remote memories[J]. Cell, 2011, 147(3): 678-689.

[11] Aponte Y, Atasoy D, Sternson S M. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training[J]. Nature neuroscience, 2011, 14(3): 351-355.

[12] Kravitz A V, Freeze B S, Parker P R L, et al. Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry[J]. Nature, 2010, 466(7306): 622-626.

[13] Amat J, Baratta M V, Paul E, et al. Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus[J]. Nature neuroscience, 2005, 8(3): 365-371.

[14] Jasmin L, Rabkin S D, Granato A, et al. Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex[J]. Nature, 2003, 424(6946): 316-320.

[15] Sunter D, Hewson A K, Lynam S, et al. Intracerebroventricular injection of neuropeptide FF, an opioid modulating neuropeptide, acutely reduces food intake and stimulates water intake in the rat[J]. Neuroscience letters, 2001, 313(3): 145-148.




    您想了解更多详细资料吗?

    请与金年会联系:

    TEL:,

         

    QQ:3007536035

    微信:yuyanbio

    Mail:

    欢迎您的咨询!

金年会 千亿球友会 千亿球友会 千亿球友会 千亿球友会 千亿球友会 千亿球友会 千亿球友会